ProBrain is a “smart drug” that claims it will regenerate your brain, helping with cell-to-cell communication, produce more neurotransmitters, and will boost your alpha waves resulting in greater intelligence, better memory, and faster processing. They state ProBrain contains natural ingredients that have been scientifically proven to work and you’ll notice a difference in your brain’s activity within 30 minutes of popping their pill.

What’s in ProBrain that makes it so great?

The sellers of ProBrain don’t tell everything that’s in it except to say it contains Bacopin along with a “custom blend of ingredients and backed by the latest science.” They add that these ingredients have been used to safely treat dementia, Alzheimer’s, ADHD, and depression. ProBrain also mentions that it targets the hippocampus, the area in the center of the brain that long-term memories are thought to be stored. They also show you some pictures of a few plants:

Screenshot of ProBrain's website

“Ok, if you say so!”

There’s also a picture of an attractive female doctor and a couple of meaningless guarantees.

A screenshot of ProBrain's website

Take 2 and call me…

When we called Probrain customer service at 1-888-896-2637 to find out more about its ingredients the line was busy.

Do smart drugs really work?

Smart drugs (sometimes called nootropics) have been around since the 1970s, when the first one called Piracetam was created by Corneliu E. Giurgea. The idea behind these drugs is that they are supposed to enhance brain function with few side effects and no psychedelic experience. There have been numerous small-scale studies of various ingredients, some of which seem to show certain ones may help with Alzheimer’s, dementia, or memory impairment.

Indeed, Bacopin (aka Bacopa Monneri), the main ingredient listed in ProBrain does have some evidence that it can help with dementia, epilepsy, and Parkinson’s Disease. A review of Bacopin research by scientists at Pitzer College it had immense potential but it is critical that more study is needed. 

But in order to be approved by the FDA as a medicine, a smart drug ingredient would have to go through a long and expensive clinical trial process; since these ingredients can’t be patented and actual proof of them working is elusive, they are instead marketed as supplement. To do this, ProBrain includes the following statement: 

“Representations regarding the efficacy and safety of ProBrain have not been scientifically substantiated or evaluated by the Food and Drug Administration.”

In spite of all the uncertainty, there is a strong interest in nootropics especially from students and Silicon Valley execs, who are always trying to gain a competitive edge. Add to that the aging Boomer population worried about “brain fog” and you have a multi-billion dollar Smart Pill industry that shows no sign of slowing.

Many reputable media outlets including Mosaic and Men’s Health Magazine have done extensive investigations on smart drugs and concluded there is little proof outside of the laboratory that any of them work to help a normal brain achieve super powers. “Part of the problem is that getting rats, or indeed students, to do puzzles in laboratories may not be a reliable guide to the drugs’ effects in the wider world,” said the article in Mosaic.

Add to the fact that we still understand very little about how the human brain works makes testing and proving cause and effect between these nootropics and our noggin difficult to pinpoint. 

And then there are some possible side effects of nootropics including headaches, nausea, dizziness, or diarrhea. 

In other words: nootropics may or may not work, but generally speaking you are going to have to be your own guinea pig. To learn more about how to choose and buy a brain supplement, read our article here

What do they charge for a bottle of ProBrain?

  • 5 bottles for $141
  • 3 for $94
  • 1 for $51.95 ($47 plus $4.95 S&H)

BUT: you are also enrolled in a sneaky auto-ship program, where they send you more bottles when you run out (depending on how many you ordered) and charge you accordingly. 

ProBrain Return Policy and Contact Info

ProBrain Terms and Condtions state that any returns are handled on a case by case basis and are restricted to one per person. Open bottles are not accepted.

The ProBrain cancellation phone number listed is (855) 511-1423 – different from the one on the front page. While this number wasn’t busy, the representative that answered said they didn’t sell ProBrain.

Bottom Line: is ProBrain a good smart drug?

As we discussed earlier, nootropics are still almost as mysterious as the human brain itself. ProBrain may make some big promises but let us remind you:

  • They don’t list all of the ingredients. Since ProBrain hasn’t been tested by an independent laboratory, there is no way to know what you are getting, aside from taking their word.
  • We had difficulty reaching them on the telephone.
  • There are no guaranteed refunds.
  • You will be subscribed to an auto-ship program.


If you are interested in learning more about smart drugs:

We suggest perusing Reddit’s A Beginner’s Guide to Nootropics. This is part of a moderated forum where individuals research and discuss firsthand the effects and side effects of various nootropic formulas.

We also recommend reading 13 Tips to Stay Smart, Sharp, and Focused from WebMD – none of them involve taking any type of pill at all. 

Let us know your experience with ProBrain below!

You may also want to read: 5 Questions to Ask Before Buying ANY Supplement Online