FootMedix by Dermal Medix uses a medical formulation of human epidermal growth factors (hEGF) to start nourishing the skin on your skin, reversing dry patches, boosting circulation, and healing fissures and calluses, within just five minutes of use.

After gently massaging a small amount into the skin of your clean, dry feet twice per day, Dr. David Watts tells us that FootMedix targets a variety of problems, including numbness, corns, and fungus.

With continued use, the website claims FootMedix can stimulate new skin growth and ultimately leave you with stronger, smoother, more attractive feet—regardless of your age or condition.

It’s no secret that FootMedix by Dermal Medix is up against a lot of competition. But before paying its meaningfully higher price, you want to learn more to help you understand if you’ll get more value for the money. Let’s dive right in and talk about hEGF.

What is Epidermal Growth Factor?

In general, a growth factor is a “naturally occurring substance [usually a protein or a steroid hormone] capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.”

There are dozens of different growth factor classes, although the relevant one here is epidermal growth factor (EGF), the discovery of which earned Stanley Cohen and Rita Levi–Montalcini the 1986 Nobel Prize in Physiology or Medicine.

When attached to its EGFR receptor, this signaling molecule has been shown in studies to cause important biochemical changes to occur inside cells and stimulate the growth of epidermal tissue (the outermost layer of skin)—meaning that it has the potential to re-grow wounded skin.

Obviously, this could be a huge benefit for those with cracked feet in need of repair. But what kind of EGF does FootMedix contain?

Are FootMedix’s Ingredients Effective For Relieving Dry, Cracked, & Calloused Feet?

Here are the ingredients listed on the Dermal Medix website:

Water, Glycerine, Glycine Soja, (Soybean) Oil, Emulsifying Wax NF, Butyrospermum Parkii (Shea Butter) Dimethicone, Alcohol, Cetearyl Alcohol, Simmondsia Chinensis (Jojoba) Seed Oil, Propylene Glycol, Glyceryl Stearate, PEG-8, PEG-100 Stearate, PEG-40 Stearate, Beta-Glucan, Glyceryl Caprylate, Tocopheryl Acetate, Panthenol, Clotrimazole, Human Oligopeptide-1, 1,2-Hexanediol, Caprylyl Glycol, Disodium EDTA, Triethanolamine, Melaleuca Alternifolia (Tea Tree) Leaf Oil

We’ll cut right to the chase and tell you that the vast majority of these ingredients are intended to change the way FootMedix feels, or the way in which it interacts with your skin (e.g. smoothness, moisturization, cleansing, etc.). The exceptions seem to be clotrimazole and tea tree oil, which are antifungal agents often found in over-the-counter medications.

While there wasn’t any clarification provided on the Dermal Medix website at the time of our research, nor any clinical evidence for support, the hEGF in FootMedix appears to be human oligopeptide-1. Here’s how Truth In Aging describes it:

“sH-Oligopeptide-1 has been labeled as a skin conditioning agent according to the Cosmetics Database. sH-Oligopeptide-1 has an identical chemical structure to an epidermal growth factor and has been shown to increase the rate of healing and renewal of the skin, as well as slow the thinning of aging skin, thus minimizing wrinkles.”

Bringing everything together, while the discovery of epidermal growth factors was obviously a big deal and EGFs, in general, have been shown to help promote wound healing, we didn't encounter any clinical evidence specifically linking sH-Oligopeptide-1 and this same effect, whether for feet or any other parts of the body.

What About FootMedix Side Effects?

Other than perhaps mild redness, it doesn’t appear that most people who use FootMedix will experience any side effects. Just keep in mind that it should only be applied to unbroken skin.

If you have any concerns, be sure to speak with your physician prior to use.

How do FootMedix’s ingredients compare to other callous creams?

FootMedix by Dermal Medix vs. the Competition

Dry, cracked, and calloused feet are nothing new, so you’ll find thousands of different formulations on the market, whether online or at your local pharmacy.

And while we didn’t encounter anything with the exact same list of ingredients as FootMedix, it’s important to remember that most of them work to soften and moisturize skin—something that can be accomplished using many different ingredients, including those found in the competition.

What about the Oligopeptide-1 found in FootMedix? We encountered several different epidermal growth factor skin creams during our research, although none that specifically used Oligopeptide-1 or that were marketed specifically for feet.

As far as FootMedix’s non-Oligopeptide-1 competitors, many can be found for as little as $8. Comparatively, what will you pay for FootMedix?

How Much Does FootMedix by Dermal Medix Cost & Where Can You Buy?

FootMedix is only available directly through Dermal Medix, priced as follows:

  • 1 Tube (about 30 days worth, when used as directed): $120
  • 2 Tubes: $228
  • 3 Tubes: $324

All FootMedix purchases come with a 90-day refund guarantee, less S&H charges, which can be requested by calling 800-425-0243 or sending an email to

Are customers finding FootMedix’s meaningfully higher price worthwhile?

What Can We Learn From FootMedix Reviews?

The only customer reviews we encountered for FootMedix during our research were on HighYa, where 60+ readers had given the cream an average rating of 4.7 stars. What was everyone saying?

Overall, most compliments appeared to reference effective results (moisturization, improved skin condition, reduced calluses and fungal infection).

In fact, more than one claimed that FootMedix was the only thing that’s worked for them after trying for decades—even some with diabetes. One reader complained about the PEG content (to which the company directly responded), while another felt the process was working, but slowly.

As far as the company goes, Dermal Medix is a sub-company of California Skin Products, LLC based out of Los Angeles, CA. Dermal Medix held an A+ rating with the Better Business Bureau, based on just one closed complaint, as of 5/3/17.

Whether positive or negative, we’re just providing you with a complete overview of the situation; this doesn’t mean you experience the same with FootMedix.

Finally, according to his LinkedIn page, Dr. David Watts founded Dermal Medix in 2010, and is also President of The American Association for Accreditation of Ambulatory Surgery Facilities, Medical Director and CEO of Watts Plastic Surgery Association, and TV Host of Plastic Surgery Issues and Answers.

Our Bottom Line About FootMedix by Dermal Medix

Taking everything we’ve learned here, it seems the two biggest differences between FootMedix’s formulation and the competition are:

  • The inclusion of Human Oligopeptide-1, which is classified as an epidermal growth factor, and a
  • Four percent concentration of dimethicone, a silicon-based polymer that can help moisturize skin and decrease itching, while also preventing moisture-related irritation (such as when wearing shoes).

Does this classify FootMedix as a “revolutionary skin repair formula,” per the product’s website? While it certainly seems to be unique, we didn’t encounter any clinical evidence during our research that these ingredients will deliver meaningful better results than other foot cream formulations.

Despite this, as well as the fact that you can purchase up to 12 tubes of the competition for the same price as one tube of FootMedix, it appears to come with almost wholly positive online customer feedback. So, in the end, it might be the case that you get what you pay for.

And if you’re ultimately dissatisfied, Dermal Medix seems to stand behind FootMedix with a 90-day refund policy, which should be more than enough time to figure out if it’s right for you. Just keep in mind you’ll be responsible for shipping it back to the manufacturer if you end up dissatisfied.