Panitrol XL is a supplement that the sellers insist is an “advanced formula” that has been clinically tested to help with stiff joints and sore muscles. They promise if you take Panitrol XL regularly you will have more mobility and less pain as you go about your daily activities. 

How Panitrol XL Works

Panitrol XL says it is a special blend of herbal ingredients that have been tested for effectiveness in reducing joint pain. The main ones are: Glucosamine HCL, Boswelia, Hyaluronic Acid, and Methyl-Sulfonyl-Methane (M.S.M.). However, they don’t include the label on the website, so you are not sure how much of each you are getting.

To use Panitrol XL, they instruct you to take it every day; they claim Panitrol XL de-sensitizes the pain receptors, supports healthy joint movement, provides antioxidants as well as building blocks that help replenish cartilage and that within a few weeks you will be able to move more easily without the “ow.” (They add in very small print that these statements have not been evaluated by the FDA and that they do not guarantee results.) 

The Panitrol XL Studies

Panitrol XL lists a few studies on their websites, which they state supports their claims that it helps reduce pain. First, they point to a study done on a combination of Glucosamine and M.S.M. that showed better efficacy in reducing pain and swelling when taken together. However, we’d like to point out that this study was done in India with just 118 patients.

A second study by an assistant clinical professor at UCLA School of Medicine on M.S.M. purports to show a better than 80% control of pain in the patients who took it. It should be noted that this was only a preliminary study which had only 16 patients. 

Finally, their main study of the actual supplement Panitrol XL says that 100% of patients who took it for 4 weeks reported no pain at all. This study was done by a company called Fenestra Research Labs, a for-hire laboratory that promises to get supplement makers the proof they need to sell products. According to one researcher, Fenestra “is not independent, is not impartial, and performs only one test of their own design which is judged by their own standards.” 

Panitrol XL Costs:

Panitrol XL offers a 60-day “risk free trial” to “qualified” consumers (meaning those that can fill out a form). The way it works is this: you pay $9.95 for the first bottle of Panitrol XL to be shipped to you and agree to sign up for their auto-ship program for 60 days. 

You will be shipped a second bottle 15 days from date of order and then every 28 days after that, each time being billed $64.97. 

If you decide you don’t want to do the 60-day trial, you must cancel within 15 days of order, and you will owe nothing further; otherwise you will have to pay for the other 2 bottles for a total of $139.89.

If you try it for 60 days and find it doesn’t alleviate pain as stated, the website says you will be eligible for a refund, minus S&H per bottle so long as you request an RMA by calling 1-877-500-5529.

Bottom Line: Is Panitrol XL a Scam?

Panitrol XL is sold by Enzyme Labs, a company that takes pride in its A+ BBB rating. We would just like to point out a couple of things.

First, the “risk free trial” is a bit confusing. Basically it seems that unless you call to cancel within 15 days of ordering (not when you receive it) you will be on the hook for at least one payment of $64.97 in addition to your initial $9.95.

Second, while the studies they cite do show potential for glucosamine-based supplements like Panitrol XL, larger studies are less conclusive. For example, Harvard Health Publications reports that a study done of 1,500 participants taking glucosamine seemed to show it provided no more relief than a placebo. Similarly, the Mayo Clinic says there is good scientific evidence for relief of knee pain, but less so for other parts of the body. Both say it’s worth trying for a few months to see if it works for you.

Glucosamine is widely available in other supplements besides Panitrol XL.

Let us know what you think of Panitrol XL – did it alleviate pain as promised or was it just a pain getting your money back?

See also: Anatomy of a Nutritional Supplement “Special Offer” Page: Tricks They Use To Get You To BUY!