Beverly Hills MD tells us that their clinically proven Line Smoothing Serum uses powerful, state-of-the-art ingredients—along with a high concentration of nutrients—to promote collagen production and cell turnover. In turn, they promise this will lead to a “dramatic” reduction in the appearance of deep wrinkles and fine lines.

But they don’t stop there. The palmitoyl peptides found in Beverly Hills MD Line Smoothing Serum claim to also deliver deep hydration, leading to plumper, firmer skin that “looks years younger.” The Botox-like SYN®-AKE might inhibit muscle contractions and reduce the appearance of expression lines. Ginkgo biloba could provide antioxidant protection, and aloe leaf extract will provide further moisturization.

Why are you here? Because you want to know if Line Smoothing Serum is worth the steep price. By the time you’re finished reading, you should be able to do just that.

What Is Collagen & Cell Turnover? Why Is It Important?

Don’t worry, we’re not going to bore you to tears. But some background information is needed to make sure we’re all on the same page.

Collagen is the most abundant protein in the human body, which (among other things) acts as a structural framework for your skin. Think of it like steel crossbeams that support an office building.

On the other hand, as cells are made, they start from lower levels of your skin and slowly make their way to the surface. Once there, they might hang out for a while before dying and being sloughed off. If you don’t regularly wash off (i.e. exfoliate) these dead cells and promote turnover, it can give your skin a less-than-stellar appearance.

Why is this important? As we age, our body produces less and less collagen and cell turnover slows, leading to dull, saggy, lifeless skin. But will Line Smoothing Serum’s ingredients help prevent this from occurring?

Before getting to that, let’s talk about one more science-y thing: absorption.

Can You Boost Collagen Using a Skin Cream?

We’re going to discuss clinical evidence in the next section. Here though, let’s talk about absorption. Or lack of thereof, as the case may be.

It seems perfectly reasonable to think that if your skin is showing the physical effects of collagen loss, rejuvenating it would be as simple as applying a cream that either a) contains collagen or B) contains ingredients that boost collagen production—as claimed by Line Smoothing Serum.

Again, the nitty-gritty details surrounding how this works is far beyond the bounds of this review, but there are two main reasons why—usually—neither of these methods are successful:

Forming Collagen Is a Multi-Step Process

First, collagen molecules in the body join together to form long fibrils (similar to strands of rope), which provide outstanding strength.

To form the collagen molecules in the first place, however, three different alpha peptides must come together and be stabilized using hydrogen bonds. This means that, even if you were to supplement your diet (i.e. ingest directly; not through the skin) with these peptides, your body will choose whether or not to pull them together and form them into collagen.

Your Skin Limits Absorption

Second, your skin is exceptionally good at keeping things out. While this prevents us from absorbing everything we touch (and consequently dying), it also means that it’s difficult to get most ingredients past our skin’s barrier and into our body where they can work their magic.

So, although BHMD’s Line Smoothing Serum might contain “high concentration of nutrients,” along with molecules that are “smaller in size,” it’s unlikely that any of them will find their way into your bloodstream.

What ingredients does Line Smoothing Serum use to get around these roadblocks? Are they really clinically proven?

How Effective Are Line Smoothing Serum’s Ingredients?

If necessary, you can quickly browse through all of Line Smoothing Serum’s ingredients on the Beverly Hills MD website. So we don’t waste your time though, we’re going to focus only on those that stand to provide you with the most benefits:

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine is the formal name for a proprietary ingredient known as SYN®-TACKS, manufactured by Center Chem. According to their website, this ingredient “significantly” stimulates protein production and increases firmness and suppleness after two months of regular use.

Dipeptide Diaminobutyroyl Benzylamide Diacetate, also known as SYN-AKE, is another proprietary ingredient. This time, it’s supposed to mimic the paralytic effects of Temple Viper venom, limiting muscle contraction and the appearance of lines and wrinkles—similar to a topical version of Botox.

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate (TAUT) is another Center Chem ingredient, which claims to boost hyaluronan content and strengthen collagen fibrils.

We’ll finish up with the final Center Chem ingredient, Palmitoyl Tripeptide-5, which promises to prevent the formation of wrinkles and to improve skin texture.

All of this sounds great, right? The problem is that, while some of these ingredients are supposed to be clinically validated, all of the studies were conducted by the manufacturer and aren’t available for third-party peer review.

Granted, Beverly Hills MD claims, “These peptides and compounds work together to create a visible result that is dramatically superior to using any of its ingredients individually.” Unfortunately, they don’t provide any clinical evidence for this.

How Much Does the Line Smoothing Serum Cost?

The acquisition costs of these proprietary ingredients are reflected in Line Smoothing Serum’s pricing:

  • 1 Bottle (1.69 fl oz): $149
  • 2 Bottles: $268.20
  • 3 Bottles: $379.95

Not happy? Beverly Hills MD provides a 60-day money back guarantee on Line Smoothing Serum by calling 877-828-5528.

The Bottom Line About Beverly Hills MD Line Smoothing Serum

It’s true that Line Smoothing Serum is doctor formulated; Drs. Payman Danielpour and John Layke, to be exact, who also run the Beverly Hills Plastic Surgery Group.

Overall, their skincare products seem to come with very positive customer reviews, who claim that they have a good skin feel, provide beneficial results (improved texture, reduced pore size, decreased lines and wrinkles), and don’t cause any side effects, even for sensitive skin.

For Line Smoothing Serum specifically, the only reviews we found were on Beverly Hills MD’s website, where it was rated an average of 4.7 stars, with many of the same compliments. Curiously, every one of these reviews was posted between 8/05/15 and 9/27/15, with not a peep since.

Based on our experience, and after reading thousands of customer reviews, it seems like even high-priced anti-aging creams rarely deliver on their promises—probably because of the absorption issue we talked about above. But Beverly Hills MD’s products come with solid customer feedback, so it might be the one-in-a-million shot for you. And as always, you can return it within 60 days if you don’t see results.